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Altered integrity of hepatocyte tight junctions in rats with triptolide-induced cholestasis / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 188-194, 2021.
Article
in English
| WPRIM
| ID: wpr-881062
ABSTRACT
Triptolide (TP), an active component of Tripterygium wilfordiiHook. f. (TWHF), has been widely used for centuries as a traditional Chinese medicine. However, the clinical application of TP has been restricted due to multitarget toxicity, such as hepatotoxicity. In this study, 28 days of oral TP administration (100, 200, or 400 μg·kg